Class 12 IB Board Psychology Project report on
CAUSES, CONSEQUENCES & TREATMENT OF
SCHIZOPHRENIA
Schizophrenia is one of the most severe mental illnesses that is
affecting 1 to 1.5 % percent population of the globe. It causes hallucinations,
paranoia or bizarre delusions and disorganized thought or speech pattern which
can result into social impairment of an individual (Sim et al. 2006). Research
indicates that People with mental illnesses die at least 25 years earlier than
the rest of the population. Schizophrenic people suffer from heart disease,
diabetes and other disease which cause their death much before than normal
population. Around 10 % of schizophrenic people die from suicide. However this
disease is now curable to an extent with advancement in medical technology,
rehabilitation process and through psychosocial interventions.
Treatment of this illness is of immense importance to save life of
millions. Possible consequences of suffering from schizophrenia do not harm
only patient but also put family into economic, mental and social loss. In
order to develop a treatment it is very important to analyse various causes
leading to this disease and understand the consequences to be faced in absence
of treatment of this disease. Over a period of time, multiple researches into
schizophrenia has been done; knowledge of this mental disorder has improved
tremendously. Researchers have pinpointed various possible causes of
schizophrenia which have helped to understand how this disease develops in an
individual and consequences to be faced in schizophrenic scenario. Causation
models assist researchers to devise cure for this disease.
This written work is based on identifying various causes of schizophrenia, its consequences and cure available to treat this mental disorder. A qualitative study has been done to achieve the objective of this work. Research work conducted in the past with regard to causes, consequences and treatment of Schizophrenia has been used to collect information material to this written work. Schizophrenia is caused due to genetic disorder, drug abuse and social environmental factors such as social exclusion, social disparity in terms of race discrimination; poor economic conditions are major causes of development of Schizophrenia. In terms of its consequences, Schizophrenia can lead to mortality, social disability, social stigma, impact caregivers and cause societal loss. Prevention intervention, family intervention, Psycho social interventions and medication are tools and strategies that can be used to cure schizophrenia.
[RBL Academy provides coaching, home tutor, online tuition, project and assignment solutions Class XI & XII Accounts, Business Studies, economics, psychology , BBA, B.Com (H), MBA, CS CA CPT, IPCC, FINAL, CMA - financial management, operation management, business statistics, operation research, corporate finance, security analysis and portfolio management, investment management, corporate tax planning, income tax and all other subjects.]
Schizophrenia is a severe mental illness that weakens mental and social functioning of an individual. It impacts perception and sensory ability and cause drastic change in behaviour of the person suffering from this ailment. This mental illness hinders social and occupational functioning of the person and causes morbidity and mortality.
In order to identify whether a person is suffering from schizophrenia
ailment, various symptoms have been identified which can be broadly classified
into major categories:
·
Auditory
hallucinations – Perceiving people talking and other sounds which are not
actually existing.
·
Sensory
feelings such as burning, stinging which does not have any real existence
·
Feeling of
disconnect from their body
·
Visualizing
images and objects which is not real.
·
Seeing things
that aren’t there, or finding light too bright or blinding.
·
Experiencing
delusions – false or erroneous belief about something.
Elements of negative symptoms include:-
·
Lack of
expression – person not interested in and around surroundings, no emotions
in voice, tone and on face.
·
Lack of
motivation – trouble in doing routine activities, facing issues in
interaction with people, feeling hazy, feels demotivate in doing anything.
·
Lack of
pleasure – remaining sad and not enjoying doing things which pleases him
and feels disconnected and disassociated with loved ones.
·
Inattention –
easily gets distracted, not able to complete his work, finds difficulty and
easily gets frustrated.
Some symptoms do not fall under either positive or negative symptoms such as:
·
Catatonia –
contortion, repetition of certain gesture, or making frenzied gestures.
·
Catatonia
inability – people remain in strange positions or gestures for very long
period of time without realization.
·
Inappropriate
effect – Responding to any stimulus in opposite way. For example on sad
news, they laugh; on good news they cry.
Numerous genetic caused
by different genes and environmental factors can lead to schizophrenia (Harrison
and Owen 2003). However it is complex to separate genetic and environmental
causes (O'Donovan et al. 2003). The theory of genetic causation firmly believes
that schizophrenia is an illness of complex inheritance. Research has been done
to identify group of genes that may cause this mental disorder (Owen et al.
2005). Result findings state that a group of fourteen genes cause this disease,
but later on it is found that suggested group of genes is not linked with schizophrenia
(Sanders et al. 2008). Schizophrenia may be caused due to duplications of DNA
sequences in genes that are conscientious for neuronal signalization or brain
development (Walsh et al. 2008). Abnormal connection between different gene
networks has been found common in schizophrenic patients (Broyd et al. 2009). Result
indicates that different neural network suppress each other leading to
deactivation of functioning of many neurons. Major symptoms of schizophrenia,
such as memory loss, attention disorder and social cognition have been
explained using this result. (ibid.).
Link between Drug use
and Schizophrenia has been established in research on effects of cannabis. It
has been suggested in the analysis of research that Drug is a vital factor that
stimulates risk of developing schizophrenia but not a significant factor in
development of this disease. It is a complex combination of factors that cause
it. (Arsenault, Cannon, Witton, &
Murray, 2004). Cannabis doubles the possibility of emergent of schizophrenia at
individual level. This connecting association accounts for 8% percent of cases
in the overall population (Arsenault et al ibid.). Hallucinogens and stimulant
drugs such as amphetamines have been linked to causing schizophrenia. Amphetamines
trigger the release of dopamine which triggers schizophrenia symptoms (Laruelle
et al. 1996). Heavy use of hallucinogens sometimes also cause trigger for schizophrenia
(Mueser at al. 1990). However, these drugs have not been necessarily caused
development of this disorder. However,
when a tendency exists, these drugs may prompt the inception of schizophrenia
(Laruelle et al. 1996).
Research indicates that social exclusion, and exploitation due to social and economic weakness present at childhood lead to high risk of developing schizophrenia in later life of individuals (Wicks et al. 2005; Mueser et al. 2004). Migration history of individual or family linked with adverse social factors such as racism, discrimination, unemployment, family dysfunction and poor economics condition are major factors causing schizophrenia (Cantor-Graae and Selten 2005; Selten et al. 2007). In particular, abusive and traumatic experiences in childhood have been identified as strong contributing factors in development of this disorder at later stage of life (Janssen et al. 2004; MacMillan et al. 2001; Read et al. 2001; Schenkel et al. 2005). Residing in urban area is one of the most vital factor in the cause of development of schizophrenia even other factors such as drug abuse, migration, social disadvantage have been restricted or controlled (van Os 2004). The chance of suffering from this disease increases with increase in number of years spent living in urban areas during childhood and adolescence (Pedersen and Mortensen 2001).
[RBL Academy provides online tuition, coaching classes, home tuition, home tutor, project and assignment solutions to XI, XII, BBA, B.COM (H), MBA & CA for subjects such as Financial Accounting, Corporate accounting, Cost & Management Accounting, Investment Management, Economics, Operation Research, statistics, Research Methodology, Marketing Management, Customer Relationship Management, financial Management, Income Tax, Indirect Tax, Company Law, Business Law, Corporate Finance, Financial Risk Management, Human Resource Management, Operation Management etc.]
Consequences of
Schizophrenia is vital in terms of losses accrue due to it. Some of the major
observations on consequences of it has been considered and explained below.
Death rates of people
having schizophrenic disorder are at least two times higher than the general
population mortality rate (Allebeck, 1989). Suicide and other causes of death
have been identified in both developing and developed countries with people
suffering from schizophrenia recent studies of people with schizophrenia living
in the community (Jablensky et al., 1992). Risk of suicide in schizophrenic
disorders has been estimated above 10 % (Caldwell and Gottesman, 1990).
·
Self Nourishment and care such as taking
care of dressing, feeding and being hygienic.
·
Occupational performance such as jobs
for which S/he gets paid, studies, homemaking etc.
·
Functioning with family and relatives in
terms of expected interaction with them.
·
Functioning in society in terms of
interaction with people and performance in social activities.
Social
stigma refers to a set of acute discrediting attributes, which is related with
wrong beliefs and negative attitudes towards a set of people from whom thay
have a fear that they can affect their social identity. These attributes lead
to distortion of their self image in society through social rejection discrimination
and social isolation (Goffman, 1963). Stigma may lead to use of derogatory
language, Obstruction to housing or employment, limited access to social
services, less chance of getting married (Desjarlais et al., 1995). Stigma also
acts as an impediment to get cured not because they will be labeled as mentally
ill because they have wrong perceptions regarding mental health feeling
dependency powerlessness segregation from society and family (Deegan, 1990).
Research indicates that people suffering from Schizophrenia who are living with their family is about 40 % in USA to more than 90 % in China (Torrey and Wolfe, 1986; Xiong et al., 1994). The burden on families or people living with mentally ill people has been recently recognised (Fadden et al., 1987). Some of the major impacts on caregivers have been analysed (Westermeyer, 1984; Davies and Drummond, 1994) such as-
·
Economic loss in terms of cost on
hospitalization and loss of productivity of family.
·
Emotional feeling towards patient
illness such as fear of loss of person, fear about future, guilty in terms of
not taking care properly etc.
·
Frustration and distress to get adapted
to disturbed behaviour.
·
Disturbance in daily routine of house;
·
Difficulties in handling awkward
interpersonal behaviour;
·
Restriction of social activities.
Subjective
emotional burden has been reported in 41% of families. Hostility, violence and
disruption of family activities were perceived as the main source of stress
(Salleh, 1994).
Estimates on economic costs of schizophrenia are existing only for some developed countries. Direct costs of schizophrenia in western countries range between 1.6% and 2.6% of total health care expenditures, which in turn account for between 7% and 12% of the gross national product. However, these costs are very unevenly distributed. According to a British study, if we consider a sample of people with schizophrenia from onset to death, it can be estimated that care of patients with long-term disabling course (which represent only 10% of the affected population) will absorb about 80% of the total lifetime direct costs. Research analysis indicates that direct and indirect cost of impact of Schizophrenia in USA in terms of per capita estimates is equal to well known chronic disease diabetes. (Report of the National Advisory Mental Health Council, 1993).
[RBL Academy provides online tuition, coaching, home tutor, home tuition, project and assignment solutions for XI, XII, BBA, B.COM, MBA, CA CPT, IPCC, Final, CS Foundation, Executive & Professional, CMA Foundation, Inter & Final. RBL Academy assists these students in almost all their subjects of their course curriculum such as Accountancy, cost Accountancy, Management Accounting, Business Law, economics, Strategic Financial Management, Income Tax, Indirect Tax, Economics, Statistics, Auditing, Business Communication, Business Ethics and all other subjects as per the requirement.]
Prevention & Treatment of
Schizophrenia
No set of treatment tool is available to cure
schizophrenia completely. However, it can be reduced to minimal and person can
come back in regular life using following treatment strategies and prevention
measures.
Preventive intervention can be categorized into primary and secondary
intervention. Primary intervention refers to reduction in incidence of illness
in a population which is not yet affected by the disease. Illness prevention
and Health Promotion are two major strategies used in primary intervention.
Illness prevention applies specific interventions by influencing risk factors
while health promotion focuses on promoting healthy behaviors in well being
(Eisenberg, 1993). Secondary prevention focuses on early identification and
diagnosis of illness to reduce morbidity through timely treatment.
Antipsychotics are used to treat Schizophrenia. These drugs treat schizophrenic psychotic symptoms by affecting dopamine system of brain. Two classes of antipsychotics drugs are available- older, first-generation medications, that usually cause more severe side effects, and newer, second-generation drugs that often cause fewer and less severe side effects. The second generation medications are usually preferred, or at least tried first, because of lesser side effects. Side effects of these drugs especially first generation can lead to diabetes, increase in weight and high cholesterol . latest guidelines on treatment of Schizophrenia prevent usage of clozapine (Clozaril) and olanzapine (Zyprexa) and recommend all other medicines before recommending these two medicines because they cause physical side effects. Treatment of schizophrenia often requires use of more than one or combination of medications to get maximum control of symptoms and minimal side effects. Treating patients with antipsychotics often requires trying more than one drug or sometimes combinations of drugs. The goal is to use the lowest dose possible to get maximum control of symptoms and the fewest and least severe side effects. To achieve that goal a patient may need to try more than one medication. (Bright Quest, USA)
This intervention refers to enhancement of resources of family in caring the person suffering from schizophrenia. Termed as Psycho educational interventions include elements (Goldstein, 1995), such as-
·
Family
engagement in early stage of treatment with no fault atmosphere
·
Creating
awareness and education about risk factors, suggestions to coping strategies
various treatment models etc.
·
Training in
communication process to increase communication clarity and sharing of negative
and positive feedback within family.
·
Problem
solving training to learn to manage day today activities, problems and stress caused
due to social events and learning to deal with anticipated stressors, coping
strategies to enhance relief.
·
Training on
Crisis intervention in case of extreme stress or when incidence of relapse are
witnesses.
A number of studies suggest that family intervention helps to reduce
relapse and increases patients’ and relatives’ satisfaction with service.
4. Other psychosocial interventions
Cognitive approach on subjective response to dysfunctional thoughts or
perceptions attempts to modify beliefs associated with delusions and ways of
coping with auditory hallucinations.This model is based on natural coping
strategies used when faced with positive symptoms of schizophrenia. It links
professional interventions with self help efforts. This model emphasizes that
psychotic symptoms prevails because of difference in thoughts rather than
different psychological processes (Chadwick et al.1996).
Social skills training refers to a group of interventions in which which
perceptual, motor and interpersonal skills are enhanced which is must to
accomplish independence good relationship in society and ease in community
survival. Complex behaviors are split into smaller elements with the help of
behavioural and social techniques such as reinforcement, role play, modeling,
behaviour rehearsal to improve the level of independency (Halford and Hayes,
1992).
Schizophrenia is a harsh mental ailment that causes 10 % of schizophrenic
people to suicide. Person suffering from this mental illness gets disconnected
from real environment due to distortion in mental ability to perceive stimulus
thus showing abnormal behaviour in all aspects of life such as while talking,
walking, sleeping and other social and functional activities of life. Major
causes leading to schizophrenia relates to genital factor and social
environmental causes. Schizophrenia can be reduced to an extent if social
discrimination among people in the society can be minimized and an adequate
balanced life could be fostered to children in the society.
Schizophrenia does not cause people to suicide but it also makes patients
socially disable, they are not able to take care of themselves, perform
occupational task and get disassociated with social activities, avoid social gathering,
feels distorted while interacting and functioning with family and society. They
get disgrace and start perceiving that they have been socially rejected. The
whole life of the person becomes an evil or curse thus they start committing
suicides.
Measures such as family intervention and preventive interventions can
serve as a tool and healing to reduce stimulant factors causing this disorder.
Medication and drugs are also used to cure this disease but side effects of
these drugs must be considered while adopting drug medication to cure it.
Psychosocial interventions such as social skills training and cognitive
approach have also proved to be productive in cure of this disease. Combination
of these preventive measures and treatment techniques under clinical guidance
and supervision can lead to minimize impact of this disease in schizophrenic
people.
References
·
Keshavan MS,
Tandon R, Boutros NN, Nasrallah HH. 2008. Schizophrenia, “just the Facts”: What
We Know in 2008 Part 3: Neurobiology. Schizophrenia Res 106(2-3): 89-107.
·
Corcoran C,
Walker E, Huot R, Mittal V, Tessner K, Kestler L, Malaspina D. 2003. The Stress
Cascade and Schizophrenia: Etiology and Onset. Schizophrenia Bull 29(4):
671-92.
·
Harris A.
2010. Pharmacological Treatment of Schizophrenia [Lecture on the Internet].
2010. Sydney: University of Sydney [cited 2010 Nov 8]. Available from
http://sydney.edu.au/medicine/psychiatry/workshops/presentations/pharmacological_treatment_schiz.pdf
·
Jones SR,
Fernyhough C. 2007. A New Look at the Neural Diathesis Stress Model of
Schizophrenia: The Primacy of Social-Evaluative Schizophrenia 13 and
Uncontrollable Situations. Schizophrenia Bull 33(5): 1171-1177.
·
Harrison PJ,
Owen MJ. 2003. Genes for schizophrenia? Recent findings and their
pathophysiological implications. Lancet 361(9355): 417-9.
·
O'Donovan MC,
Williams NM, Owen MJ. 2003. Recent advances in the genetics of schizophrenia.
Hum Mol Genet 12(2): 125-33.
·
Owen MJ,
Craddock N, O'Donovan MC. 2005. Schizophrenia: genes at last?. Trends Genet
21(9): 518-25. Pedersen CB, Mortensen PB. 2001. Evidence of a dose-response
relationship between urbanicity during upbringing and schizophrenia risk. Arch
Gen Psychiatry 58(11): 1039-46.
·
Sanders AR,
Duan J, Levinson DF, Shi J, He D, Hou C, Burrell GJ, Rice JP, Nertney DA,
Olincy A, et al. 2008. No significant association of 14 candidate genes with
schizophrenia in a large European ancestry sample: implications for psychiatric
genetics. Am J Psychiatry 165(4): 497-506.
·
Walsh T,
McClellan JM, McCarthy SE, Addington AM, Pierce SB, Cooper GM, Nord AS, Kusenda
M, Malhotra D, Bhandari A, Stray SM, Rippey CF, Roccanova P, et al. 2008. Rare
structural variants disrupt multiple genes in neurodevelopmental pathways in
schizophrenia. Science 320(5875): 539-43.
·
Broyd SJ,
Demanuele C, Debener S, Helps SK, James CJ, Sonuga- Barke EJS. 2009.
Default-mode brain dysfunction in mental Schizophrenia 12 disorders: a
systematic review. Neurosci Biobehav Rev 33(3): 279-96.
·
Arsenault L,
Cannon M, Witton J, Murray, RM. 2004. Causal association between cannabis and
psychosis: examination of the evidence. Br J Psychiatry 184: 110-7.
·
Laruelle M,
Abi-Dargham A, van Dyck CH, Gil R, D'Souza CD, Erdos J, McCance E, Rosenblatt
W, Fingado C, Zoghbi SS, et al. 1996. Single photon emission computerized
tomography imaging of amphetamine-induced dopamine release in drug-free
schizophrenic subjects. Proc Nat Acad Sci USA 93(17): 9235-40.
·
Mueser KT,
Yarnold PR, Levinson DF, et al. 1990. Prevalence of substance abuse in
schizophrenia: demographic and clinical correlates. Schizophr Bull 16 (1):
31-56.
·
Cantor-Graae
E, Selten JP. 2005. Schizophrenia and migration: a meta-analysis and review. Am
J Psychiatry 162(1): 12-24.
·
Janssen I,
Krabbendam L, Bak M, et al. 2004. Childhood abuse as a risk factor for
psychotic experiences. Acta Psychiatr Scand 109 (1): 38-45.
·
van Os J.
2004. Does the urban environment cause psychosis. Br J Psychiatry 184: 287-8.
·
Selten JP,
Cantor-Graae E, Kahn RS. 2007. Migration and Schizophrenia 16 schizophrenia.
Curr Opin Psychiatry 20(2): 111-115.
·
Schenkel LS,
Spaulding WD, DiLillo D, Silverstein SM. 2005. Histories of childhood
maltreatment in schizophrenia: relationships with premorbid functioning,
symptomatology, and cognitive deficits. Schizophr Res 76 (2-3): 273-86.
·
Pedersen CB,
Mortensen PB. 2001. Evidence of a dose-response relationship between urbanicity
during upbringing and schizophrenia risk. Arch Gen Psychiatry 58(11): 1039-46.
·
Allebeck P.
(1989). Schizophrenia: A life-shortening disease. Schizophrenia Bulletin, 15: 81-89.
·
Caldwell C.B.
and Gottesman I.I. (1990). Schizophrenics kill themselves too: A review of risk
factors for suicide. Schizophrenia
Bulletin, 16: 571-589
·
Jablensky A,
Sartorius N., Ernberg G., Anker M., Korten A., Cooper J.E., Day R., Bertelsen
A. (1992). Schizophrenia: Manifestations, incidence and course in different
cultures: A World Health Organization ten-country study. Psychological Medicine Monograph Supplement
20, Cambridge, Cambridge University Press.
·
Janca A.,
Kastrup M., Katschnig H., Lopez Ibor jr. J.J., Mezzich J.E., Sartorius N.
(1996). The World Health Organization Short Disability Assessment Schedule (WHO
DAS-S): a tool for the assessment of difficulties in selected areas of
functioning of patients with mental disorders. Social Psychiatry and
Psychiatric Epidemiology, 31: 349-354.
·
Goffman E.
(1963). Stigma. The negated identity. Englewood
Cliffs, Prentice-Hall.
·
Desjarlais R.,
Eisenberg L., Good B., Kleinman A. (1995). World mental health. Problems and priorities in low-income countries. Oxford,
Oxford University Press,.
·
Deegan P.E. (1990). Spirit breaking: When the helping professions hurt.
Humanistic Psychologist, 18: 301-313.
·
Fadden G., Bebbington P., Kuipers L. (1987). The burden of care: The
impact of functional psychiatric illness on the patient’s family. British
Journal of Psychiatry, 150: 285-292.
·
Torrey E.F. and Wolfe S.M. (1986). Care of the seriously mentally il: A
rating of state programs. Washington, Public Citizen Health Research Group.
·
Westermeyer J. (1984). Economic losses associated with chronic mental
disorder in a developing country. British Journal of Psychiatry, 144:
475-481.
·
Salleh M.R. (1994). The burden of care of schizophrenia in Malay
families. Acta Psychiatrica Scandinavica, 89: 180-185.
·
Eisenberg L. (1993). Relation between treatment and prevention
policies. In Treatment of mental disorders: A review of effectiveness.
Sartorius N., de Girolamo G., Andrews G., Allen G, Eisenberg L. (Eds.).
Washington, American Psychiatric Press, 1993.
·
(Bright Quest, USA)
(https://www.brightquest.com/schizophrenia/effective-treatment-schizophrenia/)
·
Goldstein M.J. (1995) Psychoeducation and relapse prevention,
International Clinical Psychopharmacology. 9 (suppl. 5): 59-69.
·
Chadwick P., Birchwood M., Trower P. (1996). Cognitive therapy for
delusions, voices and paranoia. Chichester, Wiley.
·
Halford W.K. and Hayes R.L. (1992). Social skills training with
schizophrenic patients. In Schizophrenia: An overview and practical handbook,
Kavanagh D.J (ed.). London, Chapman and Hall.
No comments:
Post a Comment